Enzyme Action & Specificity (Cambridge O Level Biology)

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Enzyme Action & Specificity

  • Enzymes are specific to one particular substrate(s) as the active site of the enzyme, where the substrate attaches, is a complementary shape to the substrate
  • This is because the enzyme is a protein and has a specific 3D shape
    • Different types of enzymes have a different combination of amino acids in the protein, which results in a different shape
  • This is known as the lock and key hypothesis
    • The active site is the lock and the substrate is the key 
    • Only specific shaped keys can fit into each lock

The lock and key model of enzyme action diagram

Enzyme specificity due to the lock and key model

The lock and key model of enzyme action results in enzyme specificity

Examiner Tip

Don't fall into the common trap of calling the enzyme and substrate the same shape. They are opposite, or complementary, shapes.

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Emma

Author: Emma

Expertise: Biology

Prior to working at SME, Emma was a Biology teacher for 5 years. During those years she taught three different GCSE exam boards and two A-Level exam boards, gaining a wide range of teaching expertise in the subject. Emma particularly enjoys learning about ecology and conservation. Emma is passionate about making her students achieve the highest possible grades in their exams by creating amazing revision resources!