Differentiation: GCSE Biology Definition

Emma Archbold

Written by: Emma Archbold

Reviewed by: Ruth Brindle

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1 minutes

What is differentiation?

In GCSE biology, the term differentiation refers to the process where an unspecialised cell converts into a specialised cell.

In multicellular organisms, a stem cell is an unspecialised cell that does not play a specific role in the body but is able to divide by mitosis. During development, these unspecialised stem cells change during the process of differentiation. This can involve changing size, shape or the types of organelles found in the cell. After differentiation the cell becomes a specialised cell that plays an important role in the body such as a red blood cell or a nerve cell.

Differentiation diagram

Diagram of cell differentiation showing an undifferentiated human cell with 46 chromosomes differentiating into specialised white blood and epithelial cells.
Diagram showing the differentiation of a human cell

Differentiation revision resources to ace your exams

You can explore differentiation further using our GCSE revision notes, topic questions and flashcards for your specific exam board:

Meet all your GCSE biology revision needs using our revision resources linked below. This includes revision notes, videos, flashcards and exam questions with student-friendly mark schemes.

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Emma Archbold

Author: Emma Archbold

Expertise: Biology

Prior to working at SME, Emma was a Biology teacher for 5 years. During those years she taught three different GCSE exam boards and two A-Level exam boards, gaining a wide range of teaching expertise in the subject. Emma particularly enjoys learning about ecology and conservation. Emma is passionate about making her students achieve the highest possible grades in their exams by creating amazing revision resources!

Ruth Brindle

Author: Ruth Brindle

Expertise: Biology

Ruth graduated from Sheffield University with a degree in Biology and went on to teach Science in London whilst also completing an MA in innovation in Education. With 10 years of teaching experience across the 3 key science disciplines, Ruth decided to set up a tutoring business to support students in her local area. Ruth has worked with several exam boards and loves to use her experience to produce educational materials which make the mark schemes accessible to all students.

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