Pathogens & Barriers (Cambridge (CIE) IGCSE Biology)

Revision Note

Lára Marie McIvor

Written by: Lára Marie McIvor

Reviewed by: Lucy Kirkham

Pathogens

  • A pathogen is a disease-causing organism

  • Pathogens are passed on from one host to another and therefore the diseases they cause are known as transmissible diseases

  • Pathogens can be passed on from host to host in different ways, including:

    • Direct contact - the pathogen is passed directly from one host to another by transfer of body fluids such as blood or semen (eg HIV, gonorrhoea, hepatitis B & C)

    • Indirect contact - the pathogen leaves the host and is carried by an intermediate medium or vector, such as contaminated surfaces, air (via droplets or aerosols), food, water, or organisms like insects (e.g., mosquitoes carrying malaria or dengue)

Methods of Transmission Table

Spread of Disease table, IGCSE & GCSE Biology revision notes

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The Body Defences

There are 3 main ways in which the body defends itself against disease:

1)

Mechanical barriers – structures that make it difficult for pathogens to get past them and into the body

a) Skin - covers almost all parts of your body to prevent infection from pathogens. If it is cut or grazed, it immediately begins to heal itself, often by forming a scab

b) Hairs in the nose - these make it difficult for pathogens to get past them further up the nose so they are not inhaled into the lungs

2)

Chemical barriers – substances produced by the body cells that trap / kill pathogens before they can get further into the body and cause disease

a) Mucus - made in various places in the body, pathogens get trapped in the mucus and can then be removed from the body (by coughing, blowing the nose, swallowing etc)

b) Stomach acid - contains hydrochloric acid which is strong enough to kill any pathogens that have been caught in mucus in the airways and then swallowed or have been consumed in food or water

3)

Cells - different types of white blood cell work to prevent pathogens reaching areas of the body they can replicate in

a) By phagocytosis - engulfing and digesting pathogenic cells

b) By producing antibodies - which clump pathogenic cells together so they can’t move as easily (known as agglutination) and releasing chemicals that signal to other cells that they must be destroyed

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Lára Marie McIvor

Author: Lára Marie McIvor

Expertise: Biology Lead

Lára graduated from Oxford University in Biological Sciences and has now been a science tutor working in the UK for several years. Lára has a particular interest in the area of infectious disease and epidemiology, and enjoys creating original educational materials that develop confidence and facilitate learning.

Lucy Kirkham

Author: Lucy Kirkham

Expertise: Head of STEM

Lucy has been a passionate Maths teacher for over 12 years, teaching maths across the UK and abroad helping to engage, interest and develop confidence in the subject at all levels.Working as a Head of Department and then Director of Maths, Lucy has advised schools and academy trusts in both Scotland and the East Midlands, where her role was to support and coach teachers to improve Maths teaching for all.