Glucagon in Blood Sugar Control (OCR Gateway GCSE Biology)

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Glucagon

Higher Tier Only

  • The pancreas acts as an endocrine gland, secreting the two hormones required in glucoregulation
    • Insulin - which converts glucose to glycogen (which is insoluble so can be stored for later use)
    • Glucagon - which converts glycogen to glucose (for respiration)
  • Both hormones act to maintain the blood glucose levels within the optimum limits as part of a negative feedback cycle

The negative feedback cycle

A negative feedback cycle

If the blood glucose concentration gets too low

  • Cells in the pancreas detect the decreased blood glucose levels
  • The pancreas produces the hormone glucagon and secretes it into the blood
  • Glucagon causes the glycogen stored in the liver to be converted into glucose and released into the blood
  • This increases the concentration of glucose in the blood back to normal levels, at which point the pancreas stops secreting glucagon

If the blood glucose concentration gets too high

  • Cells in the pancreas detect the increased blood glucose levels
  • The pancreas produces the hormone insulin, secreting it into the blood
  • Insulin stimulates muscles and the liver to take up glucose from the bloodstream and store it as glycogen (a polymer of glucose)
  • This reduces the concentration of glucose in the blood back to normal levels, at which point the pancreas stops secreting insulin

Negative feedback regulation of blood glucose levels

Glucose is regulated by the action of hormones insulin and glucagon

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Ruth

Author: Ruth

Expertise: Biology

Ruth graduated from Sheffield University with a degree in Biology and went on to teach Science in London whilst also completing an MA in innovation in Education. She gained 10 years of teaching experience across the 3 key science disciplines and physical education. Ruth decided to set up a tutoring business to support students in her local area. Ruth has worked with several exam boards and loves to use her experience to produce educational materials which make the mark schemes accessible to all students.