Key study one (psychological treatment for MDD): March et al. (2007)
Aim:
- To investigate the comparative effectiveness of:
- Cognitive Behavioural Therapy (CBT)
- Antidepressants (the SSRI fluoxetine)
- A combination of both CBT and antidepressants
Participants:
- 327 adolescent patients diagnosed with MDD aged 12-17 years old
- The participants came from 13 different locations in the USA
Procedure:
- The participants were randomly assigned to either the antidepressant group, the CBT group or the combination group
- The children were interviewed and their responses were measured using the Children’s Depression Rating Scale (CDRS)
- The CDRS is a list of 17 items which are rated from 1 to 7 (7 indicating extremely low mood, difficulty having fun, social withdrawal etc.)
- A score of over 40 on the CDRS is used as an indicator of MDD symptomatology
- A score of under 28 on the CDRS is used as an indicator of remission in the patient
- The study was conducted across 36 weeks
Results:
- After 36 weeks of treatment 81% of the antidepressant group, 81% of the CBT group and 86% of the combined antidepressant and CBT group showed significant improvements in their symptoms
- Suicidal ideation decreased in both the CBT group and the combination group but not to any great extent in the antidepressant group
Conclusion:
- Adolescents with MDD respond well to CBT and to CBT in combination with antidepressants
- CBT in combination with antidepressants may enhance the safety of the medication
- Overall CBT combination therapy appears to be the best course of treatment for adolescents with MDD
Evaluation of March et al. (2007)
Strengths
- The use of a randomised trial conducted across 36 weeks means that real comparisons could be made between the three groups in real time so that progress could be tracked thus increasing the validity of the findings
- The findings have great application as adolescent and child mental health is an increasingly growing cause for concern, particularly in individualistic cultures such as the USA
Weaknesses
- It is unclear as to how CBT was effective in combination with antidepressants as the two separate treatments cannot be individually assessed within the combination group which means that the study lacks explanatory power
- The research lacks predictive validity as it there was no follow-up study to assess the long-term effects of combination therapy
Mental health concerns are a growing issue for young people today