Duchenne muscular dystrophy (DMD) is a genetic disorder that leads to the degeneration of muscle tissue over time due to changes in a protein called dystrophin.
Dystrophin is a rod-shaped protein that acts as a link connecting actin filaments in muscle fibres to the extracellular matrix by attaching to a protein complex (DAPC) located in the sarcolemma.
Dystrophin is coded for by the DMD gene, and the complete protein consists of four domains (N-terminal, Rod, Cys-domain and C-terminal), as shown in the diagram below.
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The following diagram shows the regions of the DMD gene that codes for the different domains of dystrophin.
One of the causes of Duchenne muscular dystrophy is a substitution mutation that leads to the formation of a stop codon in the rod domain of the DMD gene.
Explain the impact this mutation would have on the resulting dystrophin protein by using the information in the diagrams.