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First teaching 2023

First exams 2025

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Cell Compartmentalisation (SL IB Biology)

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Cara Head

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Cara Head

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Separating The Nucleus & Cytoplasm

  • The nucleus is one of the key organelles that distinguishes eukaryotic cells from prokaryotic cells
  • It allows many cell processes to take place more efficiently than in prokaryotes
    • Gene transcription and translation are two process that occur in both eukaryotes and prokaryotes
    • In prokaryotes these processes take place simultaneously which allows for rapid responses to an environmental stimuli
    • In eukaryotes these processes occur separately due to the compartmentalisation of the nucleus
      • During transcription, mRNA is formed using a template strand of DNA; the mRNA needs some modification before it can be used for translation
      • Modification can take place in isolation within the nucleus before it comes into contact with a ribosome (this is where translation occurs) unlike in prokaryotes where the mRNA immediately meets a ribosome
      • This step reduces the chance of errors occurring in the mRNA code and therefore in the resulting protein following translation

Compartmentalisation In The Cytoplasm

  • The cytoplasm is not considered an organelle, but it's separation from organelles via their membranes is an advantage for the cell
  • Organisation of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes
  • This ensures that pathways requiring specific enzymes or metabolites run smoothly and are not at risk from interference from other cell structures or chemicals
    • Such reactions can coexist within one organelle by localising conflicting reactions, for example in plant cells a type of enzyme called nitrogenase (used for nitrogen fixation) is particularly sensitive to oxygen so it is positioned in an anaerobic part of the cytoplasm away from aerobic reactions
    • Lysosomes require lytic enzymes which could be harmful to the cell if they were not contained by the lysosome membrane
    • During endocytosis a phagocytic vacuole forms around potentially toxic and harmful substances, such as bacteria; this keeps the contents separate from the cytoplasm and rest of the cell until a lysosome can safely digest the material

Endocytosis and Phagocytosis Diagram

Phagocytosis of a bacterium

The formation of a phagocytic vacuole ensures harmful substances, such as bacteria, are kept separate from the cytoplasm and the rest of the cell

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Cara Head

Author: Cara Head

Expertise: Biology

Cara graduated from the University of Exeter in 2005 with a degree in Biological Sciences. She has fifteen years of experience teaching the Sciences at KS3 to KS5, and Psychology at A-Level. Cara has taught in a range of secondary schools across the South West of England before joining the team at SME. Cara is passionate about Biology and creating resources that bring the subject alive and deepen students' understanding