Transmission of Disease (Cambridge (CIE) AS Biology): Revision Note

Transmission of Common Diseases

Transmission of cholera

• Cholera is caused by the bacterium Vibrio cholerae

• The disease is water-borne and food-borne

• Infected people egest large numbers of the pathogenic bacteria in their faeces and water becomes contaminated

• Cholera can then be transmitted when individuals wash in contaminated water, drink contaminated water, or eat food exposed to contaminated water

• This means the disease occurs where people do not have access to proper sanitation and uncontaminated food

Transmission of malaria

• Malaria is caused by one of four species of the protoctist Plasmodium

• These protoctists are transmitted to humans by an insect vector as follows:

  • Female Anopheles mosquitoes feed on human blood to obtain the protein they need to develop their eggs

  • If the person they bite is infected with Plasmodium, the mosquito will take up some of the pathogen with the blood meal

  • When feeding on the next human, Plasmodium pass from the mosquito to the new human’s blood

• Malaria may also be transmitted during blood transfusion and when unsterile needles are re-used

• Plasmodium can also pass from mother to child across the placenta

Plasmodium spends part of its life cycle inside humans and part inside mosquitoes

Transmission of tuberculosis (TB)

• TB is cause by the bacterial pathogens Mycobacterium tuberculosis and Mycobacterium bovis

• Human to human transmission occurs by droplet infection as follows

  • When infected people with the active form of the disease cough or sneeze,  M. tuberculosis bacteria enter the air in tiny droplets of liquid

  • TB is transmitted when uninfected people inhale these droplets

  • TB therefore spreads more quickly among people living in overcrowded conditions

• The form of TB caused by M. bovis occurs in cattle but can spread to humans through contaminated meat and unpasteurised milk

  • Very few people in developed countries now acquire TB in this way, although meat and milk can still be a source of infection in some developing countries

Transmission of HIV/AIDS

• Human Immunodeficiency Virus (HIV) can infect human cells and eventually lead to AIDS

• The virus is spread by intimate human contact and can only be transmitted by direct exchange of body fluids

• This means HIV can be transmitted in the following ways:

  • Sexual intercourse

  • Blood donation

  • Sharing of needles used by intravenous drug users

  • From mother to child across the placenta

  • Mixing of blood between mother and child during birth

  • From mother to child through breast milk

Cholera, malaria, TB & HIV/AIDS summary table