The B lymphocyte Response
B-lymphocytes and the humoral immune response
- B-lymphocytes (B cells) remain in the bone marrow until they are mature and then spread through the body, concentrating in lymph nodes and the spleen
- Millions of types of B-lymphocyte cells are produced within us because as they mature the genes coding for antibodies are changed to code for different antibodies
- Once mature, each type of B-lymphocyte cell can make one type of antibody molecule
- At this stage, the antibody molecules do not leave the B-lymphocyte cell but remain in the cell surface membrane
- Part of each antibody molecule forms a glycoprotein receptor that can combine specifically with one type of antigen
- If that antigen enters the body, B-lymphocyte cells with the correct cell surface receptors will be able to recognise it and bind to it (clonal selection)
- These specific B-lymphocytes divide repeatedly by mitosis (clonal expansion) and differentiate into two main types of cell:
- Plasma cells
- Memory cells
- These two cell types each have a specific function
The maturation of B-lymphocytes – by the time a child is born, it will have millions of different types of B-lymphocytes, each with a specific antibody receptor
Primary immune response
- When an antigen enters the body for the first time, the small numbers of B-lymphocytes with receptors complementary to that antigen are stimulated to divide by mitosis
- This is known as clonal selection
- As these clones divide repeatedly by mitosis (the clonal expansion stage) the result is large numbers of identical B-lymphocytes being produced over a few weeks
- Some of these B-lymphocytes become plasma cells that secrete lots of antibody molecules (specific to the antigen) into the blood, lymph or linings of the lungs and the gut
- These plasma cells are short-lived (their numbers drop off after several weeks) but the antibodies they have secreted stay in the blood for a longer time
- The other B-lymphocytes become memory cells that remain circulating in the blood for a long time
- This response to a newly encountered pathogen is relatively slow
During a primary immune response, B-lymphocytes form two types of cell
