Population Genetics (College Board AP® Biology): Exam Questions

13 mins13 questions
1
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Mutations can occur during the process of DNA replication.

Which of the following correctly describes the role of mutation in evolution?

  • Mutations always produce beneficial traits in a population.

  • Mutations occur randomly and provide genetic variation on which natural selection can act.

  • Mutations eliminate genetic diversity by creating identical alleles.

  • Mutations only occur when an organism needs to adapt to its environment.

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Which of the following correctly explains why genetic drift impacts small populations more than large populations?

  • Chance events can cause greater fluctuations in allele frequencies in small populations.

  • Small populations experience more mutations than large populations.

  • Natural selection has a greater effect on small populations.

  • Large populations maintain constant allele frequencies, so are unaffected by genetic drift.

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31 mark

The founder effect can increase the impact of genetic drift on a population.

Which of the following is an example of the founder effect?

  • A volcanic eruption kills most members of a species, reducing genetic diversity.

  • Gene flow occurs when individuals migrate between two populations.

  • Natural selection favors a particular allele in a large population.

  • A small group of birds colonizes a new island, leading to reduced genetic variation.

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41 mark

The Hardy-Weinberg equation allows for the calculation of allele and genotype frequencies within populations.

Which of the following conditions must be met in order to accurately use the Hardy-Weinberg equation?

  • The population must be small and experience frequent migration.

  • The population must be experiencing natural selection.

  • Mutation rates must be high to increase genetic diversity.

  • There must be no natural selection or non-random mating.

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Which of the following correctly explains the effect of migration on genetic variation?

  • Migration reduces breeding between populations, so reduces genetic variation.

  • Migration increases gene flow between populations, so can introduce new alleles into a population's gene pool.

  • Migrating individuals can leave a population, meaning that migration only removes alleles, reducing genetic variation.

  • Migration means that a population no longer meets the conditions of the Hardy-Weinberg principle.

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In a large population of fruit flies, the frequency of an allele for eye color remains constant at 0.3 across many generations, despite no apparent selective advantage.

Which of the following best explains this stability in allele frequency?

  • The population is experiencing natural selection for eye color.

  • Genetic drift is causing random fluctuations in allele frequency.

  • The population meets some of the assumptions of the Hardy-Weinberg model.

  • The population is experiencing gene flow from neighboring populations.

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The ability to roll one’s tongue is under the control of a single gene. The gene has two alleles R and r. People who can roll their tongue can have the genotypes RR or Rr. People who cannot roll their tongue have the genotype rr. A survey showed that 12 % of the student population in a single school could not roll their tongues. A student used the Hardy-Weinberg equations below to calculate the number of heterozygous individuals in the school:

p + q = 1

p2 +2pq + q2 = 1

Which of the following represents the percentage of heterozygous individuals at the student’s school?

  • 88 %

  • 35 %

  • 65 %

  • 46 %

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A population of lizards (Anolis sagrei) colonized a small Caribbean island. The lizards had originally been part of a larger population on another nearby island. A team of geneticists compared the diversity of scale color alleles of the recently founded population with those of the larger source population. The frequency of scale color alleles in both populations is shown in Figure 1 below.

Bar chart showing allele frequency by scale colour. White: 0.9 founded, 0.2 source; Yellow: 0.3 source, 0.1 founded; Green: 0.4 source, 0.05 founded.
Figure 1. Scale color allele frequency in the source population and the founded population.

Which of the following conclusions is best supported by the data?

  • Natural selection has favored white scales on the small island.

  • The founder effect is affecting the lizard population on the island.

  • Mutation has given rise to new scale color alleles in the founded population.

  • Gene flow between islands has maintained similar allele frequencies.

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A population geneticist studied allele frequencies in a small, isolated population of butterflies over several generations. The frequency of a recessive allele for wing pattern was tracked, and the results are shown in Figure 1 below.

Line graph showing allele frequency changes over 10 generations, with peaks at generations 2 and 9 and a dip around generation 6, ranging from 0.4 to 0.7.
Figure 1. Allele frequency changes over several generations of butterflies.

Which of the following processes is most likely to be responsible for the observed pattern of allele frequency changes?

  • Natural selection against the recessive allele.

  • Genetic drift.

  • Gene flow from neighboring populations.

  • A consistent change in environmental conditions.

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Researchers studying a population of seed-eating finches on Daphne Major island in the Galapagos measured the beak depths of all finches on the island in 1976, then again in 1978 after a severe drought. A result of the drought was an increase in the number of large, tough seeds and a decrease in the number of small, soft seeds on the island. The beak depth measurements and population size before and after the drought are shown in the table below.

Year

Mean beak depth (mm)

Population size

1976

9.42

751

1978

9.96

90

Which of the following best explains the change in mean beak depth from 1976 to 1978?

  • The drought caused mutations to occur in the finch DNA that specifically led to an increase in beak size.

  • Overall mutation rates increased due to environmental stress.

  • A bottleneck effect has caused a random shift in allele frequencies.

  • Natural selection has increased the frequency of advantageous alleles.

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Sea otters are marine mammals that were hunted extensively for their fur during the 18th and 19th centuries. Geneticists have studied the genetic structure of sea otter populations using DNA samples from pre-fur trade otter populations and modern otter populations. The study looked at variation in the length of nuclear microsatellite DNA; short, repeating base sequences that can be located within the alleles of genes. Figure 1 compares the frequency of different forms of the Lut 453 microsatellite in pre- and post-fur trade otter populations.

Bar chart showing allele frequency percentages by allele length in base pairs. Dark bars indicate population before fur trade, light bars after the trade.
Figure 1. Allele frequencies for different lengths of the Lut 453 microsatellite in sea otter populations.

Which of the following claims is best supported by the data in Figure 1?

  • There is little gene flow between modern sea otter populations.

  • Sea otters experienced a population bottleneck due to the fur trade.

  • Modern sea otter populations show a high level of variation in the Lut 453 microsatellite.

  • The genetic structure of sea otter populations has remained largely unchanged since the 18th century.

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Figure 1 below represents the expected allele frequencies and genotypes of a population under the Hardy-Weinberg principle.

Graph showing genotype frequencies: AA, Aa, and aa, versus allele frequencies A and a. Curves are AA (decreasing), Aa (bell-shaped), aa (increasing).
Figure 1. Expected genotype and allele frequencies according to Hardy-Weinberg principle.

Which of the following correctly describes the population in Figure 1?

  • The population in Figure 1 is experiencing natural selection.

  • When the frequency of p is at 0.6, the frequency of p2 is higher than the frequency of 2pq.

  • When heterozygosity is at its highest frequency, the value of p2 is equal to the value of q2.

  • q2 becomes the most frequent genotype in the population when the frequency of q reaches 0.7.

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In the Hardy-Weinberg equation the frequency of the dominant allele is represented by p. A group of scientists used a mathematical model to predict the frequency of p in the next generation of a population, assuming that the starting frequency of p was 0.5. They calculated the predicted frequency of p in a population with:

  • 10 individuals

  • 100 individuals

  • 1000 individuals

Figure 1 shows the resulting predictions using the mathematical model. Population size is represented by N.

Three histograms showing probability vs. predicted frequency of p for sample sizes N=10, N=100, and N=1000, becoming narrower with increased N.
Figure 1. Predicted frequency of p in a subsequent generation with a starting frequency of 0.5 and in populations of different size

Which of the following correctly states the effect of population size on predicted frequency of p in a subsequent generation?

  • It is more likely that the frequency of p will decrease in a larger population than in a smaller population.

  • The probability that allele frequencies will change significantly between generations is greater in a smaller population.

  • The starting size of a population has no effect on the frequency of of p between generations.

  • It is more likely that the frequency of p will increase in a larger population than in a smaller population.

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