Random Occurrences & Genetic Diversity (College Board AP® Biology)

Mutation & Genetic Variation

Random Occurrences & the Population 

• Evolution involves changes in allele frequencies over time

• This can be caused by natural selection

  • Selection pressures (caused by the environment) increase the likelihood that certain individuals with specific alleles survive to reproductive age, enabling them to pass on their alleles to their offspring

• In addition to natural selection it is also possible for allele frequencies to change as a result of chance; for example

  • mutations

  • genetic drift

  • migration

Mutations

• The original source of genetic variation is mutation

• Mutation results in the generation of new alleles which can influence evolution of a species

• Mutations that take place in the dividing cells of the sex organs lead to changes in the alleles of the gametes that are passed on to the next generation

  • A new allele may be advantageous, disadvantageous or have no apparent effect

  • An advantageous allele is more likely to be passed on to the next generation because it increases the chance that an organism will survive and reproduce

  • A disadvantageous mutation is more likely to die out because an organism with such a mutation is less likely to survive and reproduce

• Mutations in a species are, in the long term, essential for evolution by natural selection

• Note that a mutation taking place in a body, or somatic, cell will not be passed on to successive generations, and so will have no impact on natural selection

• Mutation is the only source of variation in asexually reproducing species

Genetic Drift & Genetic Variation

Genetic Drift

• When a population is very small, chance can affect which alleles get passed on to the next generation

  • Meiosis results in haploid gametes, meaning that a fertilization event only passes on half of the alleles of an individual

  • The half that gets passed on is the result of random fertilization, and the other half of the alleles may be lost to the next generation

• Over time some alleles can be lost or passed on purely by chance; this is genetic drift

  • For this reason, genetic drift is said to be a nonselective process

• Genetic drift is more likely to affect allele frequencies in a small population

  • Eg. if a coin is tossed 10 times it is reasonably likely that heads will not come up at all, whereas if a coin is tossed 100 times and heads didn't come up at all you might suspect you had a loaded coin!

  • In a similar way the chances of a certain allele simply being lost by chance as a result of random fertilization is much greater if only 10 pairs of birds are breeding than if there were 100 pairs of birds breeding

• Reduction of genetic variation within a given population can increase the differences between populations of the same species

  • An event that leads to a reduction in the population can also cause a reduction in genetic variation

  • Which can bring in genetic drift to cause differences between populations eg. in different areas

Example of Genetic Drift in Plants

• In a small population of five plants growing near a parking lot with a rubberized floor, three of the plants have blue flowers and two of the plants have pink flowers

• By chance most of the seeds from the pink flowered plants end up on the rubberized floor of the parking lot while all the seeds from the blue-flowered plants land on fertile soil where they are able to germinate and grow

  • Note that the seeds from the pink flower do not fall on the impermeable surface because of any disadvantageous allele in the plant's genome, but purely by chance, e.g. because of a gust of wind or a passing animal

• If this happens by chance over several generations the allele for the pink flowers may be lost from this population 

The Founder Effect

• The founder effect occurs when a small number of individuals from a large parent population start a new population

  • The founder effect can come about as the result of chance

    • Eg. a chance event such as a storm may separate a small group of individuals from the main population

• As the new population is made up of only a few individuals from the original population only some of the total alleles from the parent population will be present

  • In other words, not all of the gene pool is present in the smaller population

• Because the population that results from the founder effect is very small it is more susceptible to the effects of genetic drift

The Founder Effect in Lizards

• Anole lizards (eg. Anolis sagrei) inhabit most Caribbean Islands and they can travel from one island to another via floating debris or vegetation

• A small number of lizards may be separated from the main population on a larger island and carried away to a smaller island by a chance event such as a large ocean wave or a storm

• The lizards arriving at a new island may only carry a small selection of alleles between them, with many more alleles present in the lizard population on the original island

  • Eg. the lizards on the original island could display a range of scale colors from white to yellow and the two individual lizards that arrived on the island may have white scales

    • This means that the whole population that grows on that island might only have individuals with white scales

    • In comparison the original island population has a mixture of white and yellow-scaled individuals

• If the yellow allele were recessive and present as a single copy in the original two lizards that arrived on the island, the chance of it being lost as a result of genetic drift is increased due to the small size of the gene pool

The Founder Effect in Lizards Diagram

The founder effect on lizards and their scale colors

Bottleneck Effect

• The bottleneck effect is similar to the Founder effect

• It occurs when a previously large population suffers a dramatic fall in numbers

• A major environmental event can greatly reduce the number of individuals in a population which in turn reduces the genetic diversity in the population as alleles are lost

• The surviving individuals end up breeding and reproducing with close relatives

Example of the Bottleneck Effect

• A clear example of a genetic bottleneck can be seen in cheetahs (Acinonyx jubatus) today

CC BY-SA 4.0, by Charles J. Sharp, via Wikimedia Commons

• Roughly 10,000 years ago there was a large and genetically diverse cheetah population

• Most of the population was suddenly killed off when the climate changed drastically at the end of the Ice Age

• As a result the surviving cheetahs were isolated in small populations and lots of inbreeding occurred

• This meant that the cheetah population today has a lack of genetic variation

• This is problematic for conservation as genetic variation within a species increases the likelihood that the species is able to respond in the event of any environmental changes

  • Remember the environment exerts a selection pressure on organisms

The Genetic Bottleneck Effect in Cheetahs Graph

The bottleneck effect in cheetahs after the Ice Age

Migration & Genetic Variation

• Gene flow, or migration refers to any movement of genetic material or individuals between populations

• Different populations have different gene pools with a different range of alleles

• This range of alleles can be altered if individuals from one population breed with individuals from another population

• This interbreeding allows new alleles, that have arisen through mutation, to be introduced into different populations

• Mixing gene pools in this way increases genetic variation

• Migration can also lead to genetic drift 

Processes that Cause Allele Changes Table