Krebs Cycle (College Board AP® Biology)

Study Guide

Phil

Written by: Phil

Reviewed by: Lára Marie McIvor

The Krebs Cycle

  • The Krebs cycle (sometimes called the citric acid cycle) consists of a series of enzyme-controlled reactions in the matrix of the mitochondria

  • The process is as follows

    • 2 carbon (2C) Acetyl CoA enters the circular pathway from the end of first stage of pyruvate oxidation

    • The pathway releases carbon dioxide, ATP, NADH and FADH2 from a series of organic intermediates

    • Finally the initial organic molecule is regenerated to allow the cycle to begin again

  • The products of the Krebs cycle are then used as follows:

    • Carbon dioxide is released as a waste product

    • NADH and FADH2 are transferred to the electron transport chain where they provide electrons to drive a series of REDOX reactions

The Krebs Cycle Diagram

The Krebs Cycle Diagram

The Krebs Cycle uses acetyl CoA from the oxidation of pyruvate to produce NADH, FADH2 and ATP. CO2 is lost as a waste product

Examiner Tips and Tricks

The Krebs cycle is often referred to as cyclical or circular. This is because the first organic molecule is regenerated throughout the reaction so that it can start all over again. 

Note that you are not expected to know details of the steps of the Krebs cycle or the names of the intermediate molecules 

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Phil

Author: Phil

Expertise: Biology Content Creator

Phil has a BSc in Biochemistry from the University of Birmingham, followed by an MBA from Manchester Business School. He has 15 years of teaching and tutoring experience, teaching Biology in schools before becoming director of a growing tuition agency. He has also examined Biology for one of the leading UK exam boards. Phil has a particular passion for empowering students to overcome their fear of numbers in a scientific context.

Lára Marie McIvor

Author: Lára Marie McIvor

Expertise: Biology Lead

Lára graduated from Oxford University in Biological Sciences and has now been a science tutor working in the UK for several years. Lára has a particular interest in the area of infectious disease and epidemiology, and enjoys creating original educational materials that develop confidence and facilitate learning.