Fermentation (College Board AP® Biology): Study Guide

Cara Head

Written by: Cara Head

Reviewed by: Naomi Holyoak

Updated on

Alcohol & lactic acid fermentation

  • Fermentation allows cells to continue to produce ATP when oxygen is absent

    • It is also known as anaerobic respiration

    • It produces less ATP than cellular respiration

  • The ATP produced during fermentation comes from glycolysis, which can occur without oxygen

  • Depending on cell type, the products of fermentation can include either:

    • alcohol or

    • lactic acid

Alcohol fermentation

  • Fermentation in yeast cells produces alcohol

  • Hydrogen is removed from NADH to form ethanol (alcohol) as follows:

    • pyruvate from glycolysis is converted to ethanal, releasing carbon dioxide

    • hydrogen from NADH is transferred to ethanal, producing ethanol

      • Ethanal is the hydrogen acceptor

  • The removal of hydrogen from NADH produces NAD which can re-enter glycolysis, allowing glycolysis to continue

    • This is essential because glycolysis is the process that produces ATP during fermentation

Flowchart of ethanol fermentation: Glucose to pyruvate, releasing ATP, then to ethanal. NADH converts ethanal to ethanol, releasing NAD and CO2.
Ethanol fermentation regenerates NAD and so allows glycolysis to continue producing ATP

Lactic acid fermentation

  • Fermentation in muscle cells produces lactic acid

    • This occurs when the blood cannot supply oxygen to muscles quickly enough to supply their energy needs

  • Hydrogen is removed from NADH and transferred to pyruvate, converting it to lactic acid, or lactate

    • Pyruvate is the hydrogen acceptor

  • This process regenerates NAD, allowing glycolysis to continue and meaning that muscle cells can keep on producing ATP for a short period

Flowchart showing glucose conversion to pyruvate and lactate. ATP and ADP involved. NADH and NAD cycle with 2H exchanges.
Lactate fermentation converts pyruvate to lactate, regenerating NAD and allowing glycolysis to continue

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Cara Head

Author: Cara Head

Expertise: Biology Content Creator

Cara graduated from the University of Exeter in 2005 with a degree in Biological Sciences. She has fifteen years of experience teaching the Sciences at KS3 to KS5, and Psychology at A-Level. Cara has taught in a range of secondary schools across the South West of England before joining the team at SME. Cara is passionate about Biology and creating resources that bring the subject alive and deepen students' understanding

Naomi Holyoak

Author: Naomi Holyoak

Expertise: Biology

Naomi graduated from the University of Oxford with a degree in Biological Sciences. She has 8 years of classroom experience teaching Key Stage 3 up to A-Level biology, and is currently a tutor and A-Level examiner. Naomi especially enjoys creating resources that enable students to build a solid understanding of subject content, while also connecting their knowledge with biology’s exciting, real-world applications.