Fermentation (College Board AP® Biology): Study Guide
Alcohol & lactic acid fermentation
Fermentation allows cells to continue to produce ATP when oxygen is absent
It is also known as anaerobic respiration
It produces less ATP than cellular respiration
The ATP produced during fermentation comes from glycolysis, which can occur without oxygen
Depending on cell type, the products of fermentation can include either:
alcohol or
lactic acid
Alcohol fermentation
Fermentation in yeast cells produces alcohol
Hydrogen is removed from NADH to form ethanol (alcohol) as follows:
pyruvate from glycolysis is converted to ethanal, releasing carbon dioxide
hydrogen from NADH is transferred to ethanal, producing ethanol
Ethanal is the hydrogen acceptor
The removal of hydrogen from NADH produces NAD which can re-enter glycolysis, allowing glycolysis to continue
This is essential because glycolysis is the process that produces ATP during fermentation

Lactic acid fermentation
Fermentation in muscle cells produces lactic acid
This occurs when the blood cannot supply oxygen to muscles quickly enough to supply their energy needs
Hydrogen is removed from NADH and transferred to pyruvate, converting it to lactic acid, or lactate
Pyruvate is the hydrogen acceptor
This process regenerates NAD, allowing glycolysis to continue and meaning that muscle cells can keep on producing ATP for a short period

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