Monohybrid Crosses (Edexcel A (SNAB) A Level Biology)

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Cara Head

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Cara Head

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Monohybrid Crosses

  • Monohybrid inheritance looks at how the alleles for a single gene are passed on from one generation to the next
  • Known information about the genotypes, phenotypes and the process of meiosis are used to make predictions about the phenotypes of offspring that would result from specific breeding pairs
  • When two individuals sexually reproduce there is an equal chance of either allele from their homologous pair making it into their gametes and subsequently the nucleus of the zygote
    • This means there is an equal chance of the zygote inheriting either allele from their parent
  • Genetic diagrams are often used to present this information in a clear and precise manner so that predictions can be made
    • These diagrams include a characteristic table called a Punnett square
  • The predicted genotypes that genetic diagrams produce are all based on chance
    • There is no way to predict which gametes will fuse so sometimes the observed or real-life results can differ from the predictions

F1 genetic cross

Genetic crosses can be shown by a Punnet square

Worked example

Worked example: Genetic diagram

  • One of the genes for the coat colour of horses has the following two alleles:
    • B, a dominant allele produces a black coat when present
    • b, a recessive allele produces a chestnut coat when present in a homozygous individual
  • In this example a heterozygous male is crossed with heterozygous female

Parental phenotype: Black coat x Black coat

Parental genotypes: Bb x Bb

Parental gametes: B or b x B or b

Monohybrid Punnett square with Heterozygotes Table

Monohybrid Punnett Square with Heterozygotes Table

  • Predicted ratio of phenotypes in offspring – 3 black coat : 1 chestnut coat
  • Predicted ratio of genotypes in offspring – 1 BB : 2 Bb : 1 bb

Examiner Tip

You need to be able to interpret genetic diagrams so take some time to get familiar with different sorts of diagrams such as pedigree charts and Punnet squares.

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Cara Head

Author: Cara Head

Expertise: Biology

Cara graduated from the University of Exeter in 2005 with a degree in Biological Sciences. She has fifteen years of experience teaching the Sciences at KS3 to KS5, and Psychology at A-Level. Cara has taught in a range of secondary schools across the South West of England before joining the team at SME. Cara is passionate about Biology and creating resources that bring the subject alive and deepen students' understanding