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First teaching 2023

First exams 2025

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Energy Yield: Aerobic & Anaerobic Respiration (CIE A Level Biology)

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Aerobic & Anaerobic Respiration

  • There is a much greater energy yield from respiration in aerobic conditions than in anaerobic conditions
  • In anaerobic respiration, glucose is only partially oxidised meaning only some of its chemical potential energy is released and transferred to ATP
    • The only ATP-producing reaction that continues is glycolysis (~2 ATP)

  • As there is no oxygen to act as the final electron acceptor, none of the reactions within the mitochondria can take place
    • The stages that take place inside the mitochondria produce much more ATP than glycolysis alone (~36 ATP)

Comparing aerobic & anaerobic respiration table

  Aerobic respiration Anaerobic respiration
Stages Glycolysis
Link reaction
Krebs cycle
Oxidative phosphorylation
Glycolysis
Fermentation
Oxidation of glucose Complete Incomplete
Total ATP produced High (≈36) Low (2)
Location Cytoplasm and mitochondria Cytoplasm
Products CO2, H2O Yeast: CO2, ethanol
Mammals: Lactate

Examiner Tip

You won’t be expected to know the total yield of ATP from each stage of respiration in detail but be prepared to explain why aerobic respiration produces substantially more ATP than anaerobic respiration.

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Phil

Author: Phil

Expertise: Biology

Phil has a BSc in Biochemistry from the University of Birmingham, followed by an MBA from Manchester Business School. He has 15 years of teaching and tutoring experience, teaching Biology in schools before becoming director of a growing tuition agency. He has also examined Biology for one of the leading UK exam boards. Phil has a particular passion for empowering students to overcome their fear of numbers in a scientific context.