Epigenetics & Disease
Inheritance of epigenetic modifications
- Epigenetic imprinting is the DNA methylation of certain genes and it occurs during the formation of oocytes and sperm cells
- A child, therefore, inherits two sets of DNA, one from the mother and one from the father, each with its own epigenetic imprint
- Imprinting is reversible, therefore the maternal epigenetic imprints that are inherited by a male will become paternal imprints when his sperm are produced so that he passes on paternally imprinted DNA
- Prader-Willi syndrome is an example of a condition with epigenetic links
- The syndrome is caused by the silencing of an allele on chromosome 15
- The severity of the syndrome depends on whether an individual receives the affected DNA from their mother or their father
- If the mother is a carrier for the defective chromosome, individuals that inherit the chromosome do not develop the syndrome
- However, if the defective chromosome is inherited from the father, the individual will develop the syndrome
A family tree showing the inheritance of Prader-Willi Syndrome. An individual is only fully affected by the syndrome if they inherit the faulty chromosome from their father.
Epigenetic cancer treatment
- DNA in human tumour cells have changes in DNA methylation and histone acetylation which causes tumour suppressor genes to be silenced and oncogenes to be activated
- This leads to deregulation of the cell cycle and the formation of tumours
- Some cancer treatments involve drugs that reverse the epigenetic changes through the removal of acetyl and methyl tags
- Removal of methyl groups from the DNA of tumour suppressor genes will enable the genes to be expressed
- The proteins produced can then regulate the cell cycle and stop tumours forming from faulty or cancerous cells
- Removal of acetyl groups from histone proteins attached to oncogenes causes the DNA to wrap more tightly, silencing these genes
- Reducing the expression of oncogenes stops cancer as faulty cells are able to die through programmed cell death (apoptosis) rather than continuing to replicate, causing cancer